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ChemInform Abstract: Substrate Directed Diastereoselective Hydroformylation of Acyclic Homomethallylic Alcohols.

โœ Scribed by B. BREIT

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Substrate Directed Diastereoselective Hydroformylation of Acyclic Homomethallylic Alcohols.

-Diastereoselective hydroformylation of acyclic alcohols is achieved with the aid of a catalyst-directing group. In all cases the corresponding aldehydes are formed in good yields with high anti-selectivity. The temperature dependence of the stereochemical outcome is investigated for (Ia). The anti-selectivity is rationalized by analyzing the preferred substrate conformation in solution. In accordance with the proposed model derivative (V), bearing an additional methyl group, gives even higher selectivity.

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