Substrate-Controlled Asymmetric Total Synthesis of (+)-Microcladallene B with a Bromination Strategy Based on a Nucleophile-Assisting Leaving Group

✍ Scribed by Janghyun Park; Byungsook Kim; Hyoungsu Kim; Sanghee Kim; Deukjoon Kim

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 144 KB
• Volume: 46
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200700854

✦ Synopsis

Scheme 1. Retrosynthetic analysis of (+)-microcladallene B (1). PMB = p-methoxybenzyl.

Scheme 2. Dianion alkylation of hydroxyamides. Bn = benzyl, HMDS = hexamethyldisilazide, TIPS = triisopropylsilyl.