✦ LIBER ✦

Substrate-assisted catalysis: Implications for biotechnology and drug design

✍ Scribed by Mickey Kosloff; Tsaffrir Zor; Zvi Selinger

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 133 KB
Volume: 50
Category: Article
ISSN: 0272-4391
DOI: 10.1002/1098-2299(200007/08)50:3/4<250::aid-ddr8>3.0.co;2-0

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Drug–DNA recognition: energetics and imp

Drug–DNA recognition: energetics and implications for design

✍ Ihtshamul Haq; John Ladbury 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 2 views

Implications of pharmacogenetics for ind

Implications of pharmacogenetics for individualizing drug treatment and for study design

✍ Christian Meisel; Thomas Gerloff; Julia Kirchheiner; Przemyslaw M. Mrozikiewicz; 📂 Article 📅 2003 🏛 Springer 🌐 English ⚖ 271 KB

Theoretical investigation of interaction

Theoretical investigation of interaction between Gatifloxacin and DNA: Implications for anticancer drug design

✍ Siavash Riahi; Mohammad Reza Ganjali; Mehdi Bagheri 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 856 KB

The Structure of a Designed Diiron(III)

The Structure of a Designed Diiron(III) Protein: Implications for Cofactor Stabilization and Catalysis

✍ Herschel Wade; Steven E. Stayrook; William F. DeGrado 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB 👁 3 views

Theoretical Evaluation of the Substrate-

Theoretical Evaluation of the Substrate-Assisted Catalysis Mechanism for the Hydrolysis of Phosphate Monoester Dianions

✍ Nathalie Iché-Tarrat; Manuel Ruiz-Lopez; Jean-Claude Barthelat; Alain Vigroux 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 362 KB 👁 1 views

## Abstract Quantum chemistry methods coupled with a continuum solvation model have been applied to evaluate the substrate‐assisted catalysis (SAC) mechanism recently proposed for the hydrolysis of phosphate monoester dianions. The SAC mechanism, in which a proton from the nucleophile is transferre

CD4 dimerization and oligomerization: im

CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design

✍ Song Li; Takashi Satoh; Robert Korngold; Ziwei Huang 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 946 KB

Recent studies of CD4 structure and function have revealed possible mechanisms for CD4 self-association, with implications for its role in T-cell activation. Here, the authors discuss the formulation of a hypothetical three-dimensional model of CD4 oligomerization and how it impacts on the understan