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CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design

✍ Scribed by Song Li; Takashi Satoh; Robert Korngold; Ziwei Huang

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
946 KB
Volume
19
Category
Article
ISSN
0167-5699

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✦ Synopsis

Recent studies of CD4 structure and function have revealed possible mechanisms for CD4 self-association, with implications for its role in T-cell activation. Here, the authors discuss the formulation of a hypothetical three-dimensional model of CD4 oligomerization and how it impacts on the understanding of T-cell function and rational drug design targeting specific CD4 surface functional sites.

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