Cover Picture: Automated Protein–Ligand Crystallography for Structure-Based Drug Design (ChemMedChem 8/2006)

Cover Picture: Protein-Structure-Based P

Cover Picture: Protein-Structure-Based Prediction of Animal Model Suitability for Pharmacodynamic Studies of Subtype-Selective Estrogens (ChemMedChem 11/2006)

✍ Luisella Toschi; Jochen Hilbig; Tim Wintermantel; Adelheid Engelhaupt; Alexander 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 39 KB

**The cover picture shows** a model of the binding pocket of the estrogen receptor (ER) occupied by 8β‐VE~2~, a steroidal ERβ‐selective agonist. As illustrated by the model, a single amino acid, methionine, accounts for the ERβ selectivity of this compound class. An exchange to leucine at this posit