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Substrate and product analogues as humanO-GlcNAc transferase inhibitors

✍ Scribed by Helge C. Dorfmueller; Vladimir S. Borodkin; David E. Blair; Shalini Pathak; Iva Navratilova; Daan M. F. van Aalten

Book ID
106222203
Publisher
Springer
Year
2010
Tongue
English
Weight
686 KB
Volume
40
Category
Article
ISSN
0939-4451

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✍ Florian Stolz; Astrid Blume; Stephan Hinderlich; Werner Reutter; Richard R. Schm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB

## Abstract The first step in the biosynthesis of neuraminic acid, the “epimerisation” of UDP‐GlcNAc to ManNAc, is catalyzed by UDP‐GlcNAc 2‐epimerase. In this paper we report the synthesis of the __C__‐glycosidic UDP‐GlcNAc analogues **1**−**5** as substrate‐based inhibitors of this enzyme. The fo