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C-Glycosidic UDP-GlcNAc Analogues as Inhibitors of UDP-GlcNAc 2-Epimerase.

✍ Scribed by Florian Stolz; Astrid Blume; Stephan Hinderlich; Werner Reutter; Richard R. Schmidt

Publisher
John Wiley and Sons
Year
2004
Weight
10 KB
Volume
35
Category
Article
ISSN
0931-7597

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C-Glycosidic UDP-GlcNAc Analogues as Inh
C-Glycosidic UDP-GlcNAc Analogues as Inhibitors of UDP-GlcNAc 2-Epimerase
✍ Florian Stolz; Astrid Blume; Stephan Hinderlich; Werner Reutter; Richard R. Schm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB

## Abstract The first step in the biosynthesis of neuraminic acid, the “epimerisation” of UDP‐GlcNAc to ManNAc, is catalyzed by UDP‐GlcNAc 2‐epimerase. In this paper we report the synthesis of the __C__‐glycosidic UDP‐GlcNAc analogues **1**−**5** as substrate‐based inhibitors of this enzyme. The fo