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Substrate and Inhibitor Recognition of Protein Kinases: What Is Known about the Catalytic Subunit of Phosphorylase Kinase?

✍ Scribed by Donald Graves; Cheryl Bartleson; Alyssa Biorn; Matthew Pete

Book ID: 114129523
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 355 KB
Volume: 82
Category: Article
ISSN: 0163-7258
DOI: 10.1016/s0163-7258(98)00049-7

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## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residues—Glu127, Glu170, Glu203, Glu230, and Asp241—that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant