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Substitution and elimination reactions of steroid tertiary C-17 trifluoroacetates

✍ Scribed by Ortar, Giorgio.; Romeo, Aurelio.


Book ID
127236683
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
453 KB
Volume
41
Category
Article
ISSN
0022-3263

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We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4