Synthesis and Evaluation of 17-Aliphatic Heterocycle-Substituted Steroidal Inhibitors of 17α-Hydroxylase/C17−20-Lyase (P450 17)
✍ Scribed by Hartmann, Rolf W.; Hector, Markus; Wachall, Bertil G.; Palusczak, Anja; Palzer, Martina; Huch, Volker; Veith, Michael
- Book ID
- 111888669
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 114 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-2623
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In the search for potent inhibitors of P450 17, the key enzyme of androgen biosynthesis, the 20,21-aziridinyl- and 20-aminopregnene steroids 1-11 were synthesized and tested toward rat testicular P450 17. Only the aziridinyl-substituted pregnenolones (1 and 2) and progesterones (3 and 4), respective