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Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors

โœ Scribed by Kumar, Vidya P.; Frey, Kathleen M.; Wang, Yiqiang; Jain, Hitesh K.; Gangjee, Aleem; Anderson, Karen S.


Book ID
122719395
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
811 KB
Volume
23
Category
Article
ISSN
0960-894X

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โœ Aleem Gangjee; Jianming Yu; Roy L. Kisliuk ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 94 KB

## Abstract Classical, antifolate inhibitors of thymidylate synthase often suffer from a number of potential disadvantages when used as antitumor agents. These include impaired uptake due to an alteration of the active transport system required for cellular uptake, as well as the formation of long