Substituted Azoloquinolines and -quinazolines as New Potent Farnesyl Protein Transferase Inhibitors.
โ Scribed by Patrick Angibaud; et al. et al.
- Book ID
- 101956010
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 176 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a HornerโWadsworthโEmmons procedure and a modified Michelson reaction. They have been evaluated fo
## Abstract Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to noncytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are in clinical trials. Electrospray ionization (ESI) timeโofโflight mass spectrometry (T