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Substituierte 2-Amino-thiazole aus α-Thiocyanato-acetophenonen und Dialkylaminen

✍ Scribed by Dr. sc. J. Teller; Prof. Dr. sc. H. Dehne; Dr. T. Zimmermann; Dr. habil. G. W. Fischer; Dr. B. Olk

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
451 KB
Volume
332
Category
Article
ISSN
1615-4150

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✦ Synopsis

Substituted 2‐Amino‐thiazoles from α‐Thiocyanato‐acetophenones and Dialkylamines

α‐Thiocyanato‐acetophenones 1 react with dialkylammonium salts of weak acids (acetates, propionates, benzoates) to give 2‐dialkylamino‐4‐aryl‐thiazoles 4. As reaction medium aliphatic alcohols (methanol, ethanol), dipolar‐aprotic solvents (acetonitrile, dimethylformamide, dimethyl sulphoxide) or chlorinated hydrocarbons (methylene chloride, chloroform, carbon tetrachloride) can be used. In comparison to known methods for the preparation of the thiazoles 4 the synthesis via α‐thiocyanato‐acetophenones 1 has the advantage of the simpler accessible starting compounds. – I.r., u.v., n.m.r. and mass spectroscopic data of the thiazoles 4 are reported.

📜 SIMILAR VOLUMES

Substituierte N,N′-Bis(thiazol-2-yl)-dia
Substituierte N,N′-Bis(thiazol-2-yl)-diaminoalkane aus α-Thiocyanato-acetophenonen und N,N′-Dialkyl-diamino-alkanen
✍ Dr. sc. T. Zimmermann; Dr. habil. G. W. Fischer; Dr. sc. J. Teller; Prof. Dr. sc 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 463 KB

Substituted N,N′‐Bis(thiazol‐2‐yl)‐diaminoalkanes from α‐Thiocyanato‐acetophenones and N,N′‐Dialkyl‐diaminoalkanes α‐Thiocyanato‐acetophenones 1 react with N,N′‐dialkyl‐diaminoalkanes 2 in the presence of an appropriate weak acid (acetic acid, propionic acid, benzoic acid) to give the hitherto unkn