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Substituent Effects of N-(1,3-Diphenyl-1H-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes

✍ Scribed by de Paulis, Tomas; Hemstapat, Kamondanai; Chen, Yelin; Zhang, Yongqin; Saleh, Samir; Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.; Conn, P. Jeffrey


Book ID
111937120
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
192 KB
Volume
49
Category
Article
ISSN
0022-2623

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✍ Mu-Fa Zou; Jianjing Cao; Alice L. Rodriguez; P. Jeffrey Conn; Amy Hauck Newman 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 510 KB

Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amidebased positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides. Results from an mGlu5 receptor functional a