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Substituent effects and mechanism in the micellar hydrolysis of hydroxamic acids

โœ Scribed by Berndt, Donald C.; Utrapiromsuk, Nop; Conran, Douglas E.


Book ID
126052447
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
485 KB
Volume
49
Category
Article
ISSN
0022-3263

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Rates of reaction for the alkaline hydrolysis of various hydroxamic acids in the presence of cetyltrimethylammonium bromide have been determined. Empirical reaction orders of zero, one-half, and one were found for the hydroxamic acids depending upon reaction conditions and substrate structure. N-met

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Haake and Tyssee' postulated a dissociative (Al or Al-like) mechanism for the acidcatalysed hydrolysis of diphenylphosphinanilides 1. They considered cleavage of theP-N bond in the protonated anilide to be well advanced in the transition state 2 and nucleophilic participation by water to be small. A