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Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase

✍ Scribed by Alia Al-Sarraj; Gerald Thiel


Book ID
117473196
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
156 KB
Volume
332
Category
Article
ISSN
0304-3940

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## Abstract The epidermal growth factor (EGF) receptor is highly expressed in HaCaT keratinocytes as shown by Western blotting. Stimulation of HaCaT cells with EGF, and also with the serine protease thrombin, induced DNA synthesis, measured by incorporation of 5‐bromo‐2′‐deoxyuridine into the DNA o