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Subsets of human CD4+ regulatory T cells express the peripheral homing receptor CXCR3

✍ Scribed by André Hoerning; Kerith Koss; Dipak Datta; Leonard Boneschansker; Caroline N. Jones; Ian Y. Wong; Daniel Irimia; Katiana Calzadilla; Fanny Benitez; Peter F. Hoyer; William E. Harmon; David M. Briscoe


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
596 KB
Volume
41
Category
Article
ISSN
0014-2980

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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein