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Subnanomolar Inhibitors from Computer Screening: A Model Study Using Human Carbonic Anhydrase II

✍ Scribed by Sven Grüneberg; Bernd Wendt; Gerhard Klebe


Book ID
101376820
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
254 KB
Volume
40
Category
Article
ISSN
0044-8249

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✍ A. Elisabeth Eriksson; Per M. Kylsten; T. Alwyn Jones; Anders Liljas 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 961 KB

The binding of four inhibitors--mercuric ion, 3-acetoxymercuri-4-aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion--to human carbonic anhydrase II (HCA II) has been studied with X-ray crystallography. The binding of mercury to HCA II at pH 7.0 has been investigated at 3.1 A