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Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

โœ Scribed by Leonid Kagan; Michael R. Turner; Sathy V. Balu-Iyer; Donald E. Mager


Publisher
Springer US
Year
2011
Tongue
English
Weight
536 KB
Volume
29
Category
Article
ISSN
0724-8741

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Studies on the absorption of practically
โœ Koichiro Hirano; Hideo Yamada ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 623 KB

Subcutaneous drug absorption rates from aqueous suspensions were measured in the mouse and the rabbit by a local clearance method and compared with those in the rat. A plot of the cube root of the residual fraction (W/Wo) of the drug a t the injection site uersus time ( t ) gave a good linear relati