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Studies on the absorption of practically water-insoluble drugs following injection VII: Plasma concentration after different subcutaneous doses of a drug in aqueous suspension in rats

✍ Scribed by Koichiro Hirano; Hideo Yamada

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 682 KB
Volume: 72
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600720607

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Subcutaneous drug absorption rates from aqueous suspensions were measured in the mouse and the rabbit by a local clearance method and compared with those in the rat. A plot of the cube root of the residual fraction (W/Wo) of the drug a t the injection site uersus time ( t ) gave a good linear relati