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Subchronic Physostigmine Pretreatment in Guinea Pigs: Effective Against Soman and Without Side Effects

✍ Scribed by Ingrid H.C.H.M Philippens; Ruud W Busker; Otto L Wolthuis; Berend Olivier; Piet L.B Bruijnzeel; Bert P.C Melchers

Book ID
114103821
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
68 KB
Volume
59
Category
Article
ISSN
0091-3057

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Prophylactic transdermal treatment with
Prophylactic transdermal treatment with physostigmine and scopolamine against soman intoxication in guinea-pigs
✍ Yacov Meshulam; Rachel Davidovici; Ada Wengier; Aharon Levy πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 353 KB

This study was designed to evaluate the prophylactic efficacy of transdermally administered physostigmine (PHY) against soman exposure using guinea-pigs. Transdermal PHY pad (3 cm2 kg-'; 60 p g cm-2), containing a vehicle based on propionic acid, was applied onto the dorsal back of the animals, 24 h