Subacute Sclerosing Panencephalitis: Isolation of Measles Virus from a Brain Biopsy
โ Scribed by HORTA-BARBOSA, LUIZ; FUCCILLO, DAVID A.; SEVER, JOHN L.; ZEMAN, WOLFGANG
- Book ID
- 109666502
- Publisher
- Nature Publishing Group
- Year
- 1969
- Tongue
- English
- Weight
- 128 KB
- Volume
- 221
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/221974a0
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๐ SIMILAR VOLUMES
A cytopathic measles virus was isolated from a brain biopsy of a subacute sclerosing panencephalitis (SSPE) patient. The agent could be transferred to Vero cells by cocultivation, but the infectivity always remained cell-associated -ie, a defective virus infection. The cell-associated nature of the
Antibodies to measles virus proteins in SSPE, MS and control human sera were compared using measles virus strain Edmonston, productive SSPE strain Mantooth and non-productive SSPE strain DR. The viral antigens were subjected to transfer electrophoresis, incubated with sera and localized after a seco