𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studying the synthesis of 4-tert-butyl-1,3-dihydroimidazol-2-ones and their corresponding thiones

✍ Scribed by Yasser M. Loksha; Erik B. Pedersen; Ahmed A. El-Barbary; Mahmoud A. El-Badawi; Claus Nielsen

Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
87 KB
Volume
40
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

4‐tert‐Butyl‐1,3‐dihydroimidazol‐2‐ones and 1,3‐dihydroimidazol‐2‐thiones were synthesized from 1‐amino‐3,3‐dimethylbutanone and subjected to alkylation reactions. The latter compounds were S‐alkyl‐ated with iodoacetamide under alkaline conditions. The N^1^ N^3^‐unsubstituted derivative was iodinated and subsequently alkylated with alkylation reagents which previously have been used for the synthesis of anti‐HTV active imidazoles. Unfortunately, the present products were devoid of activity against HTV.

📜 SIMILAR VOLUMES

Synthesis of derivatives of 1,3,2-diazap
Synthesis of derivatives of 1,3,2-diazaphospholidin-4-ones and the corresponding 2-sulfides
✍ Liangnian He; Yanping Luo; Mingwu Ding; Aihong Lu; Xiaopeng Liu; Tianjie Wu; Fei 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 1 views

## Abstract Aromatic‐substituted derivatives of 1,3,2‐diazaphospholidin‐4‐ones **2a–g** were readily prepared from 1,3‐diaryl glycinamides **1** by the reaction with hexaethylphosphoric triamide. Their chemical transformation was selectively effected with different thionation reagents to afford thi

ChemInform Abstract: A Novel Convenient
ChemInform Abstract: A Novel Convenient Synthesis of 1,3,4-Oxadiazol-2-ones and -thiones from N-tert-Butyldiacylhydrazines.
✍ Mark J. Mulvihill; Duyan V. Nguyen; Brian S. MacDougall; Damian G. Weaver; Willi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Preparation and Use in Amino Acid Synthe
Preparation and Use in Amino Acid Synthesis of a New Chiral Glycine Derivative – (R)- and (S)-tert-Butyl 2-tert-Butyl-4-methoxy-2,5-dihydroimidazole-1-carboxylate (BDI)☆
✍ Dieter Seebach; Matthias Hoffmann 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 612 KB

The title compound BDI is prepared on multigram scale, so clean that highly efficient in-situ double alkylations are feasible, in which the sequence of addition of the two either by resolution of the precursor 2-tert-butylimidazolidin-4-one (from glycine amide and pivalaldehyde) through different el