Synthesis of derivatives of 1,3,2-diazaphospholidin-4-ones and the corresponding 2-sulfides

✍ Scribed by Liangnian He; Yanping Luo; Mingwu Ding; Aihong Lu; Xiaopeng Liu; Tianjie Wu; Fei Cai

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 165 KB
• Volume: 12
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.1076

✦ Synopsis

Abstract

Aromatic‐substituted derivatives of 1,3,2‐diazaphospholidin‐4‐ones 2a–g were readily prepared from 1,3‐diaryl glycinamides 1 by the reaction with hexaethylphosphoric triamide. Their chemical transformation was selectively effected with different thionation reagents to afford thionated products at the phosphorus atom to give 3a–g and at the carbonyl group to give 4a. An oxidation reaction at phosphorus to produce 5a was effected with 10% hydrogen peroxide. Preliminary bioassays revealed that some of the title compounds, 2a–g and 3a–g possess selective herbicidal activity against rape. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12:497–500, 2001