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Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation

✍ Scribed by Matthew J. Betzenhauser; Larry E. Wagner II; Jong Hak Won; David I. Yule

Book ID
116986965
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
425 KB
Volume
46
Category
Article
ISSN
1046-2023

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## Abstract At the time of fertilization, an increase in the intracellular Ca^2+^ concentration ([Ca^2+^]~i~) underlies egg activation and initiation of development in all species studied to date. The inositol 1,4,5‐trisphosphate receptor (IP~3~R1), which is mostly located in the endoplasmic reticu