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Study of theophylline metabolism in premature human newborns using stable isotope labelling

✍ Scribed by J. L. Brazier; B. Ribon; M. Desage; B. Salle

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 324 KB
Volume: 7
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200070503

No coin nor oath required. For personal study only.

✦ Synopsis

A new metabolic pathway of theophylline has been investigated in premature human newborns using the ion cluster technique of stable isotope labelling combined with gas chromatography mass spectrometry. Labelled caffeine, paraxanthine and theobromine have been found in plasma and urine of two preterm newborns receiving [ 1,3-"N], [2-I3C] theophylline for the treatment of primitive apneas. Theophylline is converted to caffeine by N-7 methylation. In adults, the inverse process exists wherein caffeine is demethylated to give theophylline.

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