Study of the Reactions of Fluorine-Containing Amides with Aldehydes and the Structures of the Bisamides

✍ Scribed by Jingwei ZHAO; Yong XIN; Jun YANG; Shizheng ZHU; Liangzhong XU

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 123 KB
• Volume: 27
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200990195

✦ Synopsis

Abstract

The reactions of trifluoro or bromodifluoro acetamides with aromatic aldehydes in the presence of thionyl chloride and trifluoromethylsulfonic acid were investigated. Compared with the procedure reported previously, the yields were improved greatly and the reaction conditions were much milder. Both intra‐ and intermolecular weak interactions were discussed in detail based on the X‐ray diffraction analysis of 3aa and 3ab.