Study of the metabolism of 4-methoxy-6-aminopyrimido-(4,5-b)(1,4)-thiazine(tomizine) hydrochloride, labeled with14C and deuterium
โ Scribed by L. F. Linberg; V. A. Yadrovskaya; T. S. Safonova; Yu. N. Sheinker
- Book ID
- 112407819
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 575 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0091-150X
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Two different forms of 14C-labeled 2-methoxy-4-(methylthio)benzoic acid were prepared and employed in the synthesis of [4,5-c]pyridine hydrochloride (LY175326), a cardiotonic with inotropic and vasodilator activities that is currently in clinical trials. The synthetic procedures described i n this r
## Abstract The synthesis of 1โcyanoโ3โiminoโ8,9โdimethoxyโ โ3,4, 5,6โtetrahydroโthiazolo [4,3โa]isoquinoline hydrochloride labelled with ^14^C in five different positions: in position 3 (**1a**), in the cyano group at position 1 (**1b**), in position 5 (**1c**), in position 10b (**1d**) and in the