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Study of the mechanism of Corynebacterium Parvum anti-tumour activity. I. Protective effect on the growth of two syngeneic tumours

✍ Scribed by Cypka Mazurek; Huguette Chalvet; Claude Stiffel; Guido Biozzi

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
550 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The protective effect of C. parvum against two different tumours—a lymphosarcoma and a mammary carcinoma—has been demonstrated. In the case of lymphosarcoma, a significant protective effect was obtained when both C. parvum and tumour cells were injected IV. In contrast in C~3~H mice the best protection was obtained when both C. parvum and mammary carcinoma cells were injected IP. Thus both C. parvum and tumour cells must be inoculated by the same route which, however, varies for different tumours. A very small dose of C. parvum still inhibitied the growth of the two tumours. Splenectomy performed before C. parvum treatment did not interfere with the antitumour activity of C. parvum on the tumours. However, when splenectomy was performed after C. parvum injection, the protective effect of C. parvum still persisted against XVII lymphosarcoma but not against C~3~H carcinoma.

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