Mechanism of Corynebacterium parvum anti-tumour activity. II. Protective effect in T-cell-deprived mice
✍ Scribed by Cypka Mazurek; Huguette Chalvet; Claude Stiffel; Guido Biozzi
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 282 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult C~3~H mice or in mice thymectomized, lethally irradiated and restored with bone‐marrow cells (Tx RB). The protective effect of C. parvum was not modified by adult thymectomy but it was reduced in Tx RB mice. The injection of thymic cells to Tx RB mice or the elimination of T cell precursors in bone‐marrow cells injected in Tx RB mice did not increase the protective effect of C. parvum. These results were compatible with the hypothesis that T cells do not intervene in the mechanism of C. parvum protective effect.