✦ LIBER ✦

Study of the inclusion complexes of aromatic molecules with cyclodextrins using ionspray mass spectrometry

✍ Scribed by Paola Cescutti; Domenico Garozzo; Roberto Rizzo

Book ID: 102996529
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 518 KB
Volume: 290
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(96)00150-4

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✦ Synopsis

The formation of inclusion complexes between cyclodextrins (cyclohexa-, cyclohepta-, and cyclooctamylose) and either 1-anilinonaphthalene-8-sulfonate or 2-p-toluidinylnaphthalene-6sulfonate was investigated by ionspray mass spectrometry operated both in the positive and in the negative ion mode. This soft ionisation technique allowed the detection of the inclusion complexes; the presence of false positives was excluded by increasing the voltage at the orifice which caused breakage of the electrostatic adducts and some fragmentation of the free cyclodextrin molecules, but left the inclusion complexes intact. The spectra recorded in the negative mode showed the presence of complexes formed by two cyclodextrin molecules and one aromatic molecule; such stoichiometry was not detected in the positive mode.

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