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Study of the fast-reacting cysteines in phosphoglycerate kinase using chemical modification and site-directed mutagenesis

✍ Scribed by Philippe MINARD; Michel DESMADRIL; Nathalie BALLERY; David PERAHIA; Liliane MOUAWAD; Len HALL; Jeannine M. YON


Book ID
115126543
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
604 KB
Volume
185
Category
Article
ISSN
1432-1327

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Four residues in the carboxy-terminal domain of human epidermal growth factor (hEGF), glutamate 40, glutamine 43, arginine 45, and aspartate 46 were targeted for site-directed mutagenesis to evaluate their potential role in epidermal growth factor (EGF) receptor-ligand interaction. One or more mutat