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Study of the electroreduction of NAD and NADP coenzymes in strongly acidic media

✍ Scribed by José Miguel Rodríguez Mellado; Rafael Marín Galvín

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
470 KB
Volume
35
Category
Article
ISSN
0013-4686

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✦ Synopsis

The electroreductions of NAD and NADP coenzymes have been studied in acidic media (5 M H,SO, to pH = 2) by DP and dc polarography. Tafel slopes and reaction orders were obtained from i-E curves traced at potentials corresponding to the foot of the polarographic waves.

The results show that, at very low values of coenzyme concentration (< 5 x lo-' M) and high acidity (pH< 1), the processes are irreversible. The reduction pathways consist of the reversible transfer of an electron and an H+ ion followed by an irreversible one-electron transfer, which is the rate-determining step. At higher pH and/or concentration values this process is in competition with the electrodimerization of the coenzymes.

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