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Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus

✍ Scribed by L. Seganti; F. Superti; N. Orsi; R. Gabrieli; M. Divizia; A. Pana

Publisher: Springer-Verlag
Year: 1987
Tongue: English
Weight: 312 KB
Volume: 176
Category: Article
ISSN: 0300-8584
DOI: 10.1007/bf00189405

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✦ Synopsis

Research has been carried out in order to clarify the chemical nature of cell receptors interacting with a fast growing strain of hepatitis A virus (HAV) producing a cytopathic effect on Frp/3 cells. Cell surface susceptibility to HAV attachment has been studied after treatment with enzymes acting on different chemical groupings. Results obtained showed a lowering of cell susceptibility to HAV infection following the action of phospholipase A2, phospholipase C, trypsin and/3-galactosidase. These data suggested that phospholipids, proteins and galactose participate to the cellular receptorial area for HAV.

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