Murine Hepatitis Induced by Frog Virus 3: A Model for Studying the Effect of Sinusoidal Cell Damage on the Liver
✍ Scribed by André Kirn; Jean-Pierre Gut; Annick Bingen; Anne-Marie Steffan
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 806 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
The pathogenicity of a virus for the liver is generally related to its capacity for multiplying within the hepatic cells. Cellular damage may result either directly from replication of virus particles or indirectly from the action of immunological factors in response to the appearance of viral antigens in the hepatocyte membrane. Mouse (1) and canine (2) hepatitis illustrate the first category of diseases whereas the second type includes human hepatitis B. Frog Virus 3 (FV 3 ) hepatitis in mice and rats is, in many respects, different from the two classical types; the virus does not multiply in the organism and the target cells for the virus are the sinusoidal cells (i.e., Kupffer and endothelial cells). Hepatocellular necrosis is secondary to sinusoidal cell damage. Activation of macrophages protects the animal against hepatitis. Because of these features, the study of FV 3 hepatitis has provided interesting new aspects of hepatitis pathogenesis.
FEATURES OF FV 3 HEPATITIS
FV 3 is an icosahedral deoxyribovirus isolated from