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Study of the cellular proliferation kinetics of friend leukemia

✍ Scribed by Florence Smadja-Joffe; C. Jasmin; E. P. Malaise; Catherine Bournoutian

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
807 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

We have studied the kinetic parameters of the polycythemic variety of Friend leukemia using DBA~2~ mice inoculated with the virus. Proliferation was mainly observed in the erythroblasts of the spleen. The mean duration of the mitotic cycle is 7.6 h and the majority of erythroblasts are in active stages of the cell cycle. The proliferation rate is unaffected even during the hours preceding death. The multiplication of erythroblasts in the spleen results in three different phenomena: 1/3 of the erythroblasts produce short‐lived erythrocytes; a very small fraction (1/20) of the proliferation accounts for the slow growth of the spleen and the progressive invasion of the liver and the blood; 2/3 disappear, and this loss is apparently due to massive splenic cellular death.

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