✦ LIBER ✦

Radiosensitivity and growth of friend leukemia virus studied with the spleen focus assay method

✍ Scribed by A. A. Axelrad; S. Thomson

Publisher: John Wiley and Sons
Year: 1969
Tongue: French
Weight: 964 KB
Volume: 4
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910040208

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✦ Synopsis

Radiobiological and growth properties of a spleen focus-forming strain of Friend Leukemia Virus ( F V ) have been investigated with the spleen focus assay method. The sensitivity of FV to ultraviolet light (2537 A ) and to " T o y-rays was determined by irradiation of virus preparations in vitro to diferent doses and, at each radiation dose, measurement of the surviving fraction of spleen focus-forming activity of the virus in SIM mice. Bacteriophage T4 mixed with the virus preparations served as internal dosimeter, It was found that for UV irradiation, the D1,, of FV was 4.8 x lo3 ergs/mm2. For ionizing radiation, the Dlo of FV was 5.6 x lo4 rads.

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