Transplantation immunity and the suppression of spleen colony formation by immunization with murine leukemia virus preparations (Friend)
✍ Scribed by Charlotte Friend; Giovanni B. Rossi
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- French
- Weight
- 474 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Mice were immunized with tissue-cultured or formalin-inactivated murine leukemia virus preparations and challenged with active virus or with the virus-induced leukemic cells from established tissue culture lines. Although the virus obtained from the tissueculture system had a low leukemogenic potential, its inimunizing capacity was equal to that of the inactivated leukemic spleen filtrate virus. All preparations afforded protection against challenge with virus as well as with cells. Transplantation immunity was further demonstrated by the marked inhibition of spleen colony formation by the leukemic cells in preimmunized lethally irradiated mice.