Study of telomerase reverse transcriptase (hTERT) expression in normal, aged, and photo-aged skin
β Scribed by Enas A. S. Attia; Laila S. Seada; Mahira H. El-Sayed; Saleh M. El-Shiemy
- Book ID
- 110878982
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 345 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0011-9059
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Telomerase extends telomeric repeats at the ends of linear chromosomes, thereby prolonging the replicative capacity of cells. To investigate possible regulatory mechanisms of telomerase, we measured telomerase enzyme activity, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hT
## Abstract ## BACKGROUND Lung carcinogenesis is a multistep process of accumulation of genetic changes, including loss of heterozygosity (LOH), and precedes phenotypic transformation of the bronchial mucosa. The activity of telomerase, correlating with the hTERT mRNA expression, is detectable in