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Study of recombinant human osteogenic protein-1 expressed in prokaryocyte on the repair of extracted socket in rabbits

✍ Scribed by Yi Liu; Jin-Xiang Han; Shui-Qing Xiao; Shi-Li Wang; Min Wang

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
323 KB
Volume
77A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

The study investigated the effect of recombinant human osteogenic protein‐1 (rhOP‐1) expressed in prokaryocyte, to promote the healing of alveolar socket. A model of rabbit extracted socket into which the composites of rhOP‐1 and gelatin sponge was immediately implanted was created and the osteoinduction of rhOP‐1 was assessed by histological method, quantitative measurement of calcium content and alkaline phosphatase (ALP) activity. The result of histology showed that bone healing in rhOP‐1 side is 4–6 weeks earlier than that of the control side. ALP activity and calcium content in rhOP‐1 side were significantly high compared with that of the control side. rhOP‐1 has a satisfactory osteoinduction ability to promote the healing of extracted socket. Β© 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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