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Study of proton spin-lattice relaxation variation induced by paramagnetic antibodies

✍ Scribed by M. A. Macr; F. De Luca; B. Maraviglia; F. Polizio; G. Garreffa; S. Cavallo; P. G. Natali

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 313 KB
Volume: 11
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910110302

No coin nor oath required. For personal study only.

✦ Synopsis

A murine anti-human melanoma monoclonal antibody fragment was labeled with gadolinium and its proton relaxation efficiency compared to controls at frequencies ranging from 2 to 300 MHz. Relaxation time variations were about 30-40% in 10-15 microM solutions. The labeled fragment showed proton relaxation enhancement relative to free gadolinium, while preserving its immunoreactivity. A tentative labeling of a melanoma pellet by means of the fragment, just at the borderline of a minimum expected T1 variation, gave no detectable difference.

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