Study of brain microvessels by automatic image analysis
β Scribed by V. S. Shinkarenko; V. N. Larina
- Publisher
- Springer US
- Year
- 1982
- Tongue
- English
- Weight
- 433 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0007-4888
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π SIMILAR VOLUMES
To study the transport system of propranolol (PL), a basic drug, in the blood-brain barrier, the uptake of PL into isolated bovine brain microvessels was investigated. The uptake of PL was a concentrative one via saturable process (Km = 42.5 microM) that was decreased by hypothermia (Q10 = 2.2), but
## Abstract Animal studies have shown that in vivo estimates of microvessel density in the brain may be obtained from an MRIβmeasurable index (__Q__) provided that a sufficiently high dose of an intravascular paramagnetic contrast agent is employed. __Q__ is determined from the shifts in the transv