✦ LIBER ✦

Study of behavioral phenotypes: Goals and methodological considerations

✍ Scribed by Finegan, Jo-Anne

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 16 KB
Volume: 81
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980328)81:2<148::aid-ajmg5>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

The study of behavioral phenotypes associated with genetic syndromes has gained increasing momentum over the past two decades. In this paper, the definition of behavioral phenotypes is presented and the complexities and obstacles to progress in this field are summarized. Also described are the goals of such investigations, including the need for syndrome delineation, provision of guidance for clinical management, contributions to understanding brainbehavior relations, advancements in developmental theory, and gaining understanding of the genetic bases of behavior. Methodological issues addressed in relation to such goals include the need for crossdisciplinary collaboration, concerns regarding sampling methods and comparison group selection, and developmental considerations. The complexity of cognitive abilities, the limitations of existing tests and measures, and ways of approaching the study of behavior are discussed. A final comment concerns the potential risks of research in behavioral phenotypes. Am. J.

📜 SIMILAR VOLUMES

Behavioral phenotypes: Conceptual and me

Behavioral phenotypes: Conceptual and methodological issues

✍ Flint, Jonathan 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 18 KB 👁 2 views

Specific behavioral patterns associated with chromosomal and genetic disorders are being recognized more frequently. The hope is that the demonstration of a behavioral phenotype with a particular syndrome may lead to the isolation of the behavior's genetic determinants. Three issues are considered h

Genetic linkage study of panic: Clinical

Genetic linkage study of panic: Clinical methodology and description of pedigrees

✍ Fyer, Abby J.; Weissman, Myrna M. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 19 KB 👁 1 views

This paper describes the clinical methodology and currently collected pedigrees from an ongoing genetic study of panic disorder. The main objectives are to (1) document the clinical aspects of the study for current [

Genotype, molecular phenotype, and cogni

Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome

✍ Kaufmann, Walter E.; Abrams, Michael T.; Chen, Wilma; Reiss, Allan L. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 2 views

The study of the neurobehavioral consequences of mutations of FMR1, the gene responsible for fragile X syndrome (FraX), has been based largely on correlations between mutation patterns and cognitive profile. Following the characterization of FMRP, the FMR1 gene product, preliminary correlations betw

Behavioral phenotype of smith-magenis sy

Behavioral phenotype of smith-magenis syndrome (del 17p11.2)

✍ Smith, Ann C.M.; Dykens, Elizabeth; Greenberg, Frank 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 40 KB 👁 1 views

## Smith -Magenis syndrome (SMS) is a distinct and clinically recognizable multiple congenital anomaly (MCA) and mental retardation syndrome caused by an interstitial deletion of chromosome l7 p11.2. The phenotype of SMS has been well described and includes: a characteristic pattern of physical fe

Analysis of the tricho-dento-osseous syn

Analysis of the tricho-dento-osseous syndrome genotype and phenotype

✍ Tim Wright, J.; Kula, Katherine; Hall, Kathie; Simmons, Joey H.; Hart, Thomas C. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

The tricho-dento-osseous (TDO) syndrome demonstrates kinky curly hair, thin-pitted enamel, taurodontism, and thickening of cortical bone. The purpose of this investigation was to characterize the phenotypic variation of TDO in 3, previously unreported, kindreds and to examine possible candidates for

Of Gods and Goats

✍ Richard S. Shaver 📂 Fiction 📅 2010 🌐 UND ⚖ 34 KB 👁 2 views