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Behavioral phenotypes: Conceptual and methodological issues

✍ Scribed by Flint, Jonathan

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 18 KB
Volume: 81
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980508)81:3<235::aid-ajmg6>3.0.co;2-v

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✦ Synopsis

Specific behavioral patterns associated with chromosomal and genetic disorders are being recognized more frequently. The hope is that the demonstration of a behavioral phenotype with a particular syndrome may lead to the isolation of the behavior's genetic determinants. Three issues are considered here: the problem of defining a behavioral phenotype, the difficulty of demonstrating the existence of a behavioral phenotype, and the likelihood of characterizing etiologically important genes. Although there are many impediments to success, the value of recognizing behavioral phenotypes within a diagnostic syndrome is emphasized, and examples are given of how this may lead to isolating behavioral genes.

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