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Studies with polyfunctionally substituted heteroaromatics: 2-Phenyl-4-p-tolylhydrazono-2-oxazoline-5-one as a precursor for the synthesis of substituted 1,2,4-triazoles and pyridines

✍ Scribed by Mohamed Hilmy Elnagdi; Abdalla Mohamed Negm; Ayman Wahba Erian; Salah El-Kousy

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
296 KB
Volume
6
Category
Article
ISSN
1042-7163

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✦ Synopsis

2-PhenyC4-p-tolylhydrazono-2-oxazoline-5-one (3)

was rearranged by the action ofphenols and naphthols into 1,2,4-triazole-5-carboxylic esters (5) that were rearranged further o n reflux in AcOH-ZnCl, into triazolyl ketones (7). Rearrangement of 3 into 1,2,4-triazole derivatives could also be effected by the action of heterocyclic amines and I-naphthylamine. 0 1996 John Wiley & Sons, Inc.

Polyfunctionally substituted heteroaromatics are interesting as potential pharmaceuticals [ 1,2], agrochemicals [3-51, and dye intermediates [6,7]. Because neither classical synthetic approaches of heterocycles nor functionalization reactions of aromatics can easily be applied for preparation of this class of compounds , developing new approaches for the synthesis of these compounds has received

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