Studies towards the synthesis of the marine metabolite, octalactin A

✍ Scribed by Alison N. Hulme; Garnet E. Howells

• Book ID: 104258221
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 263 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10127-7

✦ Synopsis

Studies towards the synthesis of the marine metabolite octalactin A 1, are described. Key steps in this strategy include an anti aldol reaction to set the C7-Cs stere~ehemisla'y, Homer Wadsworth Ernmom coupling to give the trisubstituted E-double bond and a novel samarinm-mediated cyclisation reaction.