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Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning

✍ Scribed by Kazuo Yabu; Shuji Masumoto; Motomu Kanai; Dennis P. Curran; Masakatsu Shibasaki

Book ID: 104250874
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 128 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00451-3

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✦ Synopsis

Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent syntheses of camptothecin (Curran's intermediate and Corey's intermediate) were obtained in up to 10 g scale through the catalytic enantioselective cyanosilylation of ketones.

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