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Catalytic Enantioselective Synthesis of (20S)-Camptothecin Intermediates Using Cyanosilylation of Ketones Promoted by D-Glucose-derived Lanthanide Catalyst

โœ Scribed by Shibasaki, Masakatsu; Yabu, Kazuo; Masumoto, Shuji; Kanai, Motomu; Du, Wu; P. Curran, Dennis


Book ID
111964198
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
126 KB
Volume
59
Category
Article
ISSN
0385-5414

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Studies toward practical synthesis of (2
โœ Kazuo Yabu; Shuji Masumoto; Motomu Kanai; Dennis P. Curran; Masakatsu Shibasaki ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 128 KB

Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent syntheses of camptothecin (Curran's intermediate and Corey's intermediate) were obtained in up to 10 g scale through the catalytic enantioselectiv