𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies on vitiligo. II. Familial aggregation and genetics

✍ Scribed by S. K. Das; Dr. Partha P. Majumder; T. K. Majumdar; B. Haldar; D. C. Rao

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
435 KB
Volume
2
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Data on 298 pedigrees, each collected through an affected proband, have been analyzed to study familial aggregation and genetics of vitiligo. The extent of familial aggregation is statistically significant at the 5 % level. The disease does not appear to be inherited in a simple dominant or recessive fashion. The heritability of liability to the disease is 46% f 4.82%. Neither common family environment nor a major locus with additional sources (environmental and/or polygenic) can be excluded as a cause of familial aggregation. Association of the disease with six polymorphic genetic marker loci have been studied. Significant associations with ACPl and RH loci have been found. This and earlier studies indicate that the disease is associated with genetic loci on different chromosomes, which points to a polygenic nature of the disease.

πŸ“œ SIMILAR VOLUMES

Power calculations for familial aggregat
Power calculations for familial aggregation studies
✍ Nusrat Rabbee; Rebecca A. Betensky πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 142 KB

## Abstract Family studies are frequently undertaken as the first step in the search for genetic determinants of disease. Significant familial aggregation of disease is suggestive of a genetic etiology for the disease, and may lead to more focused genetic analyses. Many methods have been proposed i

Genetic studies on familial leukemia
Genetic studies on familial leukemia
✍ Soji Kurita; Yoshitaka Kamei; Kazuo Ota πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 328 KB πŸ‘ 2 views

Familial leukemia in Japan was studied. Among 20 families where familial leukemia occurred in siblings, in 6 of them (30%) the parents were first cousins, in 2 (10%) each they were first cousins once removed and second cousins, while among 200 families where nonfamilial leukemia occurred, only in 9

Genetic and family studies
Genetic and family studies
✍ ROBERT W. Miller πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 61 KB πŸ‘ 2 views
Familial aggregation of dyslexia phenoty
Familial aggregation of dyslexia phenotypes. II: Paired correlated measures
✍ Hsu, Li ;Wijsman, Ellen M. ;Berninger, Virginia W. ;Thomson, Jennifer B. ;Raskin πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 94 KB

## Abstract Dyslexia is a common and complex behavioral disorder characterized by unexpected difficulty in learning to read. Psychometric measures used to assess dyslexia often evaluate overlapping processes or abilities. To identify subphenotypes amenable to model‐based linkage analyses, we have u

Studies on vitiligo I. Epidemiological p
Studies on vitiligo I. Epidemiological profile in Calcutta, India
✍ S. K. Das; Partha P. Majumder; Ranajit Chakrabotry; T. K. Majumdar; B. Haldar; D πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 492 KB

An epidemiological profile of vitiligo in Calcutta is presented. Prevalence data were gathered from 15,685 individuals drawn from the general population; pedigree data were collected through 293 vitiligo patients. The overall prevalence of vitiligo is about 5 per 1,OOO individuals. There are no sign