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Studies on uracils: synthesis of novel pyrido[2,3-d]pyrimidine oxides via ring transformation of isoxazolo[3,4-d]pyrimidine

✍ Scribed by P.J Bhuyan; H.N Borah; R.C Boruah

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 184 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00115-1

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✦ Synopsis

The reaction of isoxazolo [3,4-d]pyrimidine 1 and cyanoolefins 2 in the presence of triethylamine (Et 3 N) as a catalyst afforded an unprecedented one-pot synthesis of biologically important pyrido [2,3-d]pyrimidine oxides 3 in excellent yields.

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